Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1032 | Male Reproduction | ICEECE2012

New insights into sperm DNA methylation: intra-and inter individual stability and a comparative analysis versus somatic cells

Krausz C. , Sandoval J. , Chianese C. , Giachini C. , Sayols S. , Esteller M.

Data about the entire sperm DNA methylome are limited to two sperm donors whereas studies dealing with a greater number of subjects focused only on a few genes or were based on low resolution arrays. This implies that information about what we can consider as a normal sperm DNA methylome and whether it is stable among different normozoospermic individuals is still missing. The definition of the DNA methylation profile of normozoospermic men, the entity of inter-individual vari...